statin과 microbiome의 관계

https://medicalxpress.com/news/2020-06-gut-microbiota-cholesterol-lowering-medication.html

 

Scientists have previously found an association between the gut microbiota and various metabolism-related and cardiovascular diseases. Now the current study, published in the journal Nature, shows improvement in gut microbiota in the participant group who were taking statins.Scientists have previously found an association between the gut microbiota and various metabolism-related and cardiovascular diseases. Now the current study, published in the journal Nature, shows improvement in gut microbiota in the participant group who were taking statins. The direct mechanisms have not been identified.

"Although the study does not provide a causal link," he says, "it's exciting to see how a well-established and clinically used drug can change the gut microbiota. Time will tell whether statins affect bacteria in the gut directly or whether these drugs affect both gut and immune cells that, in turn, help modify the microbiota."

The gut microbiota is divided into various main groups, known as enterotypes, that vary among individuals. One of these, labeled Bact2, has fewer bacteria in terms of number and composition alike. Microbes lacking in Bact2 include anti-inflammatory bacteria like Faecalibacterium, one effect of which is to strengthen the immune system.

Bact2 is more common in patients with inflammatory bowel disease (IBD), multiple sclerosis and depression. In the current study, the scientists found this enterotype also to be significantly more prevalent in patients with obesity (18%) than people without it (4%)—an observation verified in an independent Belgian study.

The positive and hitherto unknown effect of statins identified by the researchers was that the proportion of individuals with Bact2 decreased in the group given statin therapy, resulting in a more normal gut microbiota.

 

 

 

reference

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis, Nature (2020). DOI: 10.1038/s41586-020-2269-x