유방암진단 Lab-on-a-Chip

https://medicalxpress.com/news/2020-06-lab-on-a-chip-blood-breast-cancer-early.html

 

모르는 단어

supplant: replace

mammogram: the process of using low energy X-ray to diagnose and screening.

 

Xu and his colleagues tested their lab-on-a-chip by equipping one of its channels to look for MMP14, an enzyme released by tumors that has been linked to cancer progression. The enzyme attacks healthy cells in ways that seem to promote the spread of cancer.

In early tests focused on MMP14, the device detected early-stage or metastatic breast cancer with 97% accuracy in a first group of 30 people and 93% in a second group of 70 people

This new technology is one of many efforts to develop a "liquid biopsy" that would use blood tests to find cancer

Tumors shed many different types of chemicals and matter into the bloodstream, and these telltale signs could help detect cancer that's not yet advanced.

Such a liquid biopsy could one day supplant mammograms as the initial screening tool for breast cancer

"This is not limited to breast cancer," Xu said. "MMP14 exists in many, many other types of cancer."

 

MMP14를 capturing 한다고 되어있는데, 논문 제목은 EV(Extracellular Vescicle) analysis라고 되어있다. 

그래서 논문을 읽어보았다. 

There is growing evidence indicating important functions of extracellular vesicles (EVs) in tumor progression and metastasis, including matrix remodeling via transporting matrix metalloproteases (MMPs).

Distinct from existing technologies mostly focused on characterizing molecular constituents of EVs, here we report a nanoengineered lab-on-a-chip system that enables integrative functional and molecular phenotyping of tumor-associated EVs.

A generalized, high-resolution colloidal inkjet printing method was developed to allow robust and scalable manufacturing of three-dimensional (3D) nanopatterned devicesㅁ

나중에 더 읽어보자. 일단 과제 끝내자

 

 

reference

Peng Zhang et al. Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis, Science Translational Medicine (2020). DOI: 10.1126/scitranslmed.aaz2878