https://medicalxpress.com/news/2020-06-rod-shaped-particles-distract-out-of-control-covid.html
The No. 1 cause of death for COVID-19 patients echoes the way the 1918 influenza pandemic killed: their lungs fill with fluid and they essentially drown. This is called acute respiratory distress syndrome. But a new way of drawing immune cells out of the lungs might be able to prevent this outcome.
ARDS is a manifestation of a condition known as cytokine storm, in which the immune system overreacts and begins attacking the person's own organs. In ARDS, out-of-control white blood cells break down lung tissue and cause fluid to build up. Helping to lead the charge is a type of white blood cell called the neutrophil, which makes up 60% to 70% of intruder-eating "phagocyte" cells in humans.
Neutrophils aren't specialized, which enables them to respond to many threats, she explained. But sometimes, that lack of specialization means they don't know when to quit.
"As long as there's cues, neutrophils keep acting. In some instances, the feedback loop is broken, and that turns what is meant to be a good response into a bad response,"
One of their actions is to emit signaling molecules called cytokines that tell cells to break down barriers and let blood and fluid into a problem site. When that response turns bad, the neutrophils need to be stopped so that other cells can step in and repair the damage.
Previously, Eniola-Adefeso's group showed that plastic microparticles injected into the blood of mice could distract neutrophils, diverting them away from areas of severe inflammation in their lungs. The neutrophils would grab the particle and head to the liver to dispose of it. Microplastics used in this way eased ARDS in mice.
But any type of phagocyte might take up a sphere, which means a sphere-based therapy is likely to affect other parts of the immune response. However, it was already known that other phagocytes aren't fond of rod-shaped particles. Eniola-Adefeso said they "get lazy" with the long wrapping process around a rod.
And that preference is useful for targeting neutrophils and leaving other white blood cells
to do their jobs. They found that when they offered rods to different phagocytes, 80% of the neutrophils ate them, whereas only 5% to 10% of other phagocytes did. The comparisons included macrophages, another cell that eats intruders, and dendritic cells, which capture intruders and then show the other immune cells what to look for.
The team is currently exploring whether neutrophil-distracting particles can be made from medications rather than plastic.
reference
"Neutrophils preferentially phagocytose elongated particles—Opportunity for selective targeting in acute inflammatory diseases" Science Advances (2020). advances.sciencemag.org/content/6/24/eaba1474