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amyloid beta가 neuronal cell membrane에 주는 영향 the cause of neuronal death is still unknown. The treatments available are aimed at slowing down the development of dementia and only help to improve quality of life for short periods. have revealed for the first time the atomic structure of amyloid-beta (Aβ) protein assemblies. The knowledge of this structure reveals a new mechanism of toxicity for these assemblies, with the capacity to disrupt..
pH와 Macrophage의 영향 Cellular waste disposal, where autophagy and lysosomes interact, performs elementary functions, such as degrading damaged protein molecules, which impair cellular function, and reintroducing the resulting building blocks such as amino acids into the metabolic system. Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin have now discovered a previously unkn..
시냅스의 functional and structural change의 correlation https://medicalxpress.com/news/2020-06-weaken-notion-size-equals-strength.html Learning, memory and behavioral disorders can arise when the connections between neuron, called synapses, do not change properly in response to experience. could yield new treatments for a disorder called Fragile X that causes autism. Two classic forms of synaptic plasticity are that synapses either get stronger or we..
항산화제와 치매 Research from The University of Western Australia has found a diet rich in nutrients and antioxidants may prevent or even reverse the effects of Alzheimer's disease. Chronic degenerative diseases such as Alzheimer's are attributed to more than 70 percent of deaths globally and oxidative stress, chronic metabolic acidosis and free radicals in the body play a key role in the aging process. The res..
과식과 면역반응. Researchers at Yale have identified a molecule that plays a key role in the body's inflammatory response to overeating, which can lead to obesity, diabetes, and other metabolic diseases. When a person overeats, the body stores excess calories in the form of fat in the adipose tissue, or body fat As the amount of calories consumed continues to increase, this leads to inflammation in adipose tissu..
스트레스와 brown fat의 관계... In the face of psychological stress, an immune system response that can significantly worsen inflammatory responses originates in brown fat cells, the Yale team reports June 30 in the journal Cell. Since the hormones associated with stress, cortisol and adrenaline, generally decrease inflammation, it has long puzzled researchers how stress can worsen health problems such as diabetes and autoimmu..
mircro-biome의 byproduct (causing oxidative stress)로 인한 aging https://medicalxpress.com/news/2020-06-arteries-age-explores-link-gut.html A compound produced in the gut when we eat red meat damages our arteries and may play a key role in boosting risk of heart disease as we get older, according to new University of Colorado Boulder research. "Our work shows for the first time that not only is this compound directly impairing artery function, it may also hel..
deformed protein folder (chaperone)'s influence In molecular biology, chaperones are a class of proteins that help regulate how other proteins fold. Folding is an important step in the manufacturing process for proteins. When they don't fold the way they're supposed to, it can lead to the development of diseases such as cancer. Researchers at the Sloan Kettering Institute have uncovered important findings about what causes chaperones to malfu..