근육과 면역의 관계

https://medicalxpress.com/news/2020-06-muscles-strong-immune.html

 

In many cases, severe weight loss and a decrease in muscle mass are the result of cancer or dangerous infections. In addition to this process known as cachexia, patients often suffer from a weakened immune system. One of the reasons for this is a loss of function of a group of T-cells, whose task it is to recognize and kill virus-infected cells or cancer cells.

"It is known that T-cells are involved in the loss of skeletal muscle mass. But whether and how, in turn, skeletal muscles influence the function of the T-cells is still unclear,"

To find out, the scientists infected mice with lymphocytic choriomeningitis virus (LCMV). This method is a widely used model system to study the course of acute or chronic infections in mice. The researchers then analyzed the gene expression in the skeletal muscles of the animals and found that in chronic infections, the muscle cells release an increased amount of the messenger substance interleukin-15. This cytokine causes T-cell precursors to settle in the skeletal muscles. As a result, they are spatially delimited and protected from contact with the chronic inflammation.

"If the T-cells, which actively fight the infection, lose their full functionality through continuous stimulation, the precursor cells can migrate from the muscles and develop into functional T-cells,"

So could regular training strengthen the immune system? "In our study, mice with more muscle mass were better able to cope with chronic viral infection than those whose muscles were weaker. But whether the results can be transferred to humans, future experiments will have to show," 

 

모르는 것

precursor?

In biochemistry, the term "precursor" often refers more specifically to a chemical compound preceding another in a metabolic pathway, such as a protein precursor. 

 

reference

Jingxia Wu et al, Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion, Science Advances (2020). DOI: 10.1126/sciadv.aba3458